New study says glyphosate may be linked to neurodegenerative diseases
By Luyi Cheng
Glyphosate, the world’s most widely used weed killer, can reach the brain and cause inflammation associated with neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease, according to new research. These findings add to growing concerns that glyphosate and other pesticides are leaving a damaging impact on human health and the environment.
The results mark the first time scientists have identified glyphosate present in brain tissue, said Ramon Velazquez, an assistant professor studying neurodegenerative diseases at Arizona State University and a senior author of the study
Velazquez and a team of other scientists from Arizona State University, the City of Hope Comprehensive Cancer Center, and the Translational Genomics Research Institute published their work late last month in the Journal of Neuroinflammation.
Health concerns over glyphosate exposure
Glyphosate, also known as the active ingredient in Roundup, is the most used herbicide in the United States. It is popular with farmers who use it in their fields, and is also used in forestry management and for treating weeds in residential lawn and garden settings. A June report by the Centers for Disease Control and Prevention found that over 80 percent of urine samples collected from adults and children in the United States contained detectable levels of glyphosate.
The World Health Organization’s International Agency for Research on Cancer concluded that glyphosate is “probably carcinogenic to humans” in 2015. In 2019, more research tied glyphosate exposure to a 41% higher risk of cancer, specifically non-Hodgkin lymphoma. A series of court trials in the United States have also accused Monsanto of hiding the cancer risks of its Roundup products.
Despite the concerns about the health effects of glyphosate exposure, the Environmental Protection Agency (EPA) still declares that they have found “no risks of concern to human health when glyphosate is used in accordance with its current label” and that “glyphosate is unlikely to be a human carcinogen.”
Potential implications for neurodegenerative diseases
In addition to finding glyphosate in brain tissue, the study authors also found higher levels of an signaling molecule that causes inflammation, called TNFa, in the glyphosate-exposed mice.
While healthy adult brains are expected to have low levels of TNFa, brains with neurodegenerative diseases have much higher levels of TNFa. According to the study, the subsequent elevated levels of TNFa in the brain after glyphosate exposure “may have implications for neurodegenerative disorders such as Alzheimer’s Disease.”
The researchers conducted their study by dosing mice with glyphosate. After 14 days of exposure, they found the herbicide present in their brain tissue. To collect evidence that glyphosate could be connected to neurodegenerative diseases, the research team applied glyphosate to samples of brains cells extracted from the mice. After 24 hours, they found that the glyphosate exposure triggered the cells to increase production of a protein considered a hallmark of Alzheimer’s Disease.
According to Velazquez, it’s important to note that the glyphosate doses tested on the mice in this study (ranging between administering 250 and 500 milligrams of glyphosate per kilogram of mouse body weight per day) are higher than the typical daily exposure to humans. However, the doses are based on other past mice research and are still within the “maximum dose at which there is no significant toxic effect” for mice, initially established by the EPA. According to the study, the results “still hold value” in providing evidence of the potential consequences of glyphosate exposure.
More research is definitely needed, said Velazquez. “I think that this is an important first step: showing that [glyphosate] gets into the brain and induces these changes.”
The research team is continuing to study both the longer-term consequences of glyphosate, as well as human-relevant doses, in mice.
August 27, 2022 @ 11:43 pm
All I know that is every time our neighbors would spray their lawn, because heaven forbid, they would get dandelions, my lips would feel numb and I would be at the opposite of the our house from where they were spraying and didn’t even know that was what was causing it, until I was outside once when they were doing it. Later, they quit when their grandson had health issues and the doctor suggested they didn’t use it. That was back in the 90’s. I’ve also heard that dogs get throat cancers from eating grass that’s been sprayed with it.
August 27, 2022 @ 8:05 pm
LIBERTY LINK FROM BAYER!!!!!
LIBERTY LINK replacing ROUNDUP
August 27, 2022 @ 7:41 pm
IMPORTANT TO READ: Do humans have a shikimate pathway?
Although it is widely recognised that many microorganisms rely on the shikimate pathway for aromatic amino acid biosynthesis, the extent to which this pathway is active in the human gut microbiome is unknown. We show that the shikimate pathway is present in almost all individuals (Fig. 1B).Jun 10, 2020
https://www.sciencedirect.com › pii
Computational modelling provides insight into the effects of …
The way glyphosate (Roundup) reached the marketplace two absolutes had to be overlooked by trained scientists. First, scientists at the EPA HAD TO BELIEVE THAT GLYPHOSATE IS NOT AN ANTIBIOTIC. All human beings have more bacteria than cells. We cannot think, procreate, eat, take nourishment, digest food, or evacuate without the microbiome. When Alexander Fleming developed antibiotics he stated that this cure would likely end all life on earth. This Monsanto discussion is as serious as an atomic bomb. Roundup disables the “bugs” we need in our gut. It is true that humans don’t have the shikamate pathway. The bugs in our gut do! Many people are getting many illnesses due to glyphosate. I cannot scientifically prove this but common sense sometimes prevails. Unless you’re a corporation.
The second absolute involves the shikamate pathway which the EPA stated was not found in mammals. I’m a chemically injured (by pesticides) person so I read whatever I can. Monsanto or Bayer or Dow or whoever owned glyphosate (Roundup) neglected to learn before getting Roundup into our rain that without the shikamate pathway humans cannot make amino acids. I’ll post a list of the amino acids below.
Because glyphosate (the weed killer Roundup) which is going to be renamed BTW is also an antibiotic, try to imagine soil life after years of killing soil life. Monsanto and now Dow created a monster in our soil so that we’re dependent on them. They modified our seed to grow only with their chemicals. AND both the antibiotic and shikamate bug dependency in our gut are affected.
List of amino acids our gut needs to stay well.
The Twenty Amino Acids
The twenty amino acids (that make up proteins)each have assigned to them both three-letter (can be upper or lower case) and one-letter codes (upper case). This makes it quicker and easier for notation purposes and are worth learning. The following list gives these notations along with hypertext references to download amino acid gif images and also interactive molecules.
The format of the list is: amino acid name – 3 letter code – 1 letter code (reference to gif image, reference to interactive molecule)
alanine – ala – A (gif, interactive)
arginine – arg – R (gif, interactive)
asparagine – asn – N (gif, interactive)
aspartic acid – asp – D (gif, interactive)
cysteine – cys – C (gif, interactive)
glutamine – gln – Q (gif, interactive)
glutamic acid – glu – E (gif, interactive)
glycine – gly – G (gif, interactive)
histidine – his – H (gif, interactive)
isoleucine – ile – I (gif, interactive)
leucine – leu – L (gif, interactive)
lysine – lys – K (gif, interactive)
methionine – met – M (gif, interactive)
phenylalanine – phe – F (gif, interactive)
proline – pro – P (gif, interactive)
serine – ser – S (gif, interactive)
threonine – thr – T (gif, interactive)
tryptophan – trp – W (gif, interactive)
tyrosine – tyr – Y (gif, interactive)
valine – val – V (gif, interactive)
Sometimes it is not possible two differentiate two closely related amino acids, therefore we have the special cases:
asparagine/aspartic acid – asx – B
glutamine/glutamic acid – glx – Z
Manganese is depleted in Roundup soil so make your own decision about that but see Amazon.com
So, if you don’t know 10 people with cancer already, you probably don’t ever leave your house!
Since my husband died from GSK’s AVODART life for me is very different. I’m severely chemically sensitive but I traveled to stay with my family in a country that BANS GMO’s and I got well! We’re breathing, eating, and standing in rain filled with Glyphosate (roundup) soon to be renamed by Bayer. Bayer is one of the premier German chemical companies. If you don’t know why Germany developed so many chemicals that kill people google Nazi Germany Gas Chambers World War II.
Please stop eating (unless organic) soy, wheat, oats, Cheerios, corn, animals fed corn, and eat five organic vegetables a day. I’m not a doctor but I have common sense.
Dig a victory garden and eat only from it. Do the best you can or do this for young children. Try other than non-organic soy formula.
There are organic foods that build gut flora. Organic kimchee comes to mind. Please educate yourself. Many mainstream doctors, Li, Fung, and others are now on YouTube because of years of failures doling out useless drugs. All the above is my opinion. Find a literate doctor before trying anything dangerous like digging a garden or changing your meds.
BTW when I returned to the US I was sick again within two weeks beginning with pharyngitis. I eat only organic food but I’m going to leave the US in order to seek a country that doesn’t have Roundup in its rain.
I’m going to post the NEW NAME FOR ROUNDUP TODAY BUT I’ll need to find a video and read it. I’ll post bith names 25 times. I’m hoping people organize not to buy glyphosate no matter what they name it.
August 27, 2022 @ 6:19 pm
This link is on YouTube. It discusses Monsanto using the EPA to prevent misinformation from being leaked. Please take time to watch because one woman made it her life’s work to prove much of what we know about Monsanto now Bayer.
August 27, 2022 @ 5:24 pm
Round up and the entire array of new chemicals that have been invented in the last 100 years, in their entire cocktail on this planet, which we are all exposed to, is evidently causing all the “modern” health problems already mentioned above. A few greedy jerks, not very ecologically educated, only care about seed and chemical patents, profits, and we all speed up towards our graves. Puppet politicians that approve whatever the corporations dictate, etc. We all know what is going on.
August 27, 2022 @ 4:59 pm
I’m going to comment on “that which is generally recognized as safe” or GRAS and NOEL in response to a respected post I’ve read up above by Gustavo. That which we have been taught should always be questioned.
I’d first question GRAS. Please acknowledge my request by visiting EWG.org. It is of particular interest to me that GRAS infers foods, chemicals, and ag products overseen by the EPA (was organized by Richard Nixon) are “Generally Accepted as Safe” but that “implied promise” simply has NEVER been held to a high standard.
I point to inappropriate appointed officials from industry referred to as “the revolving door” 30 years ago; untrained individuals; and FDA overloaded so as to be incapable of retesting findings. GRAS IS ACTUALLY ESTABLISHED BY DRUG, CHEMICAL AND AGRICULTURE researchers. Researchers are paid by industry to produce results that get products to market often. The information is then accepted as “accurate and true” by the FDA UNLESS inaccuracies are found in the information provided to them. Corporate “choice of facts” given to the FDA is well known. It would take 100,000 armies to redo all research presented to the FDA.
I sat in on a 12 hour FDA approval session for the drug AVODART. At least two doctors on a 12 team board had accepted “speaking fees” from Glaxo Smith Kline. (Illegal by FDA standards.) Avodart killed my husband. I have a dog in this fight! He was the only father of my children. He was the only man I ever loved. I have trouble going to sleep and getting out of bed. Why? It was clearly stated during the FDA meeting by a physician NOT ON GSK’s PAYROLL, “We will kill some men.” The decision was made to “kill some men.” My husband was one of those men who were chosen as if we live in Nazi Germany.
MY HUSBAND DIED SO A DRUG THAT DID NOT WORK, could reach the market. I sued and like many other Avodart widows, I WON.
I was able to get a black box warning on the label. Years later the death warning was removed. “Avodart for Black Men” was introduced. It apparently explained the reason all races were not included in the study.
So, please begin to look at reality. My husband WAS NOT BLACK but I can only imagine how many black men died after Avodart caused formation of a toxic level of testosterone. The drug also skewed PSA readings such that the number had to be doubled. Certainly a Princeton Grad could double a number. But the label did not state “double the PSA.” Watching this man be cremated haunts me.
Much of the meeting rested on previous assumptions of safety.
To go into GRAS: Skittles is a Candy. It seemed addictive to me. I had to purposely stop eating Skittles at my friend’s house. My friend who appeared to have symptoms of Altzheimers (a kind soul to be exact) consumed Skittles year after year after year. Titanium Dioxide in Skittles is GRAS approved but was recently studied. The studies prove Skittles can and does CHANGE DNA! The last time I saw my friend she thanked me for helping her arrange a family reunion and then she asked my name. After my husband died this sweet woman slept in my bed to comfort me and cared for me. No Skittles is not the entire picture, but she might know who I am if her condition did not also interface with Candy she ate.
NOEL— yes there are levels of pesticides that have a designation that is referred to as a Noel. But that is not the entire picture. Many people do not read the box if they are sweating and cannot see, and many people are not properly dressed if they are not aware of the dangers of pesticides sold for use around the home. As a victim of an overspray, I can say that there are many ways that Noel does not protect anyone at all. My husband sold jets for LM, And we moved a lot. We leased a house. We were not aware that our lawn was being sprayed and that we were eating from an organic garden I planted in the same yard. I put in the organic garden about the time we moved into the house one spring. During that same spring every single lawn in the neighborhood in Connecticut had a ChemLawn truck outside and after they left there were dead birds everywhere. You might be interested to know that up to 70% of all birds in this country have disappeared. Each time a lawn was sprayed, one of my children was walking through these lawns to get to and from school. He was not applying the pesticides. My son went to Princeton University but he is chemically sensitive. This condition is not highly recognized because it is directly connected to injury by industry. I cannot understand how anyone could live in this country and not understand that Noel is meaningless. I want to cite a second example of my understanding of Noel.
American corporations went to India and set up banks so that Indians could begin using pesticides on their crops. They were given genetically modified seed possibly by Monsanto or Dow. I read this years ago and don’t recall. Essentially they were hooked into a system and they could not get out of it the second year. When they realized that they could not collect the seed from the year before and they could not afford to buy all of the chemicals that they had been given loans to buy, many became despondent. Many actually drank the pesticides that they had left over. The pesticide became useful to them in an act of suicide because it allowed their widows to get life insurance so that they could continue for a couple more years after their death. So in my opinion Noel has absolutely no meaning when corporations go into a country with the intention of hooking a nation on a product. But I would like to talk about Noel in a fashion that will probably appeal to your knowledge more.
Since I have been exposed to Roundup, other organophosphate pesticides and I have been the victim of an overspray Noel is meaningless to me because I cannot be near any petroleum product at all. I am now getting older but was 36 years old when I had my exposure. I had a husband from Princeton University I had 5 year degree in design and I had two beautiful children one of whom also went to Princeton University. I had a new baby upstairs and went to stretch my legs in the back yard. A lawn sprayer was tree spraying when I was nearby behind a hedge. I’ve never recovered. Everyone in my family suffered from an illness following living in the house where Noel was in effect.
We were eating organic food. Every single thing that I gave my children and my husband to eat was organic. How in the world could anyone believe that NOEL could protect us?
We bring Mexicans into this country and we do not test them to see how they metabolize pesticides. Not all people can metabolize pesticides. Many of the women who work in the fields in our country are pregnant.. in some trimester of pregnancy the fetus can be severely injured from pesticides. Can you tell me how NOEL affects the fetus? Is NOEL safe for the fetus in the first trimester?
There is a phenomenon called individual variability. Are we just going to throw those people away because they are not just exactly like the people tested and put on paper and given to the FDA? Or are we going to ban together and begin to grow our food organically? Are we really seriously going to give two or three corporations ownership of all seed in this country? Are we going to seriously damage all of our soil rendering it lifeless? Are we going to irrevocably damage all of our water? How far are we willing to go to bow down to Dow Chemical company and Monsanto?
I respectfully ask you to consider this in addition to the science that you obviously know very well. There is another branch of science that is referred to as ethics. I believe that ethics should precede all scientific investigation and all use of products that are labeled GRAS.
It is my understanding that a corporation murdered my husband and I have absolutely no way of seeing that corporation imprisoned. If we cannot live with the consequences of GRAS and NOEL, Isn’t it time that we develop another better and safer way of dealing with medicine and food in this country?
Please watch these videos by an intelligent and trained physician responsible for creating chemotherapy agents. He has changed. Can others?
God bless you as you decide which side you stand on. I hope I have convinced you that without your knowledge someone you love dearly is getting sick, carrying an autistic child, suffers from allergies, will develop cancer, diabetes or become mentally ill. ALL HEALTH DEPENDS ON GUT FLORA. If we don’t change we will all suffer these things in our families alone without a support system at all. The medical profession is dying of self hate.
August 27, 2022 @ 3:34 pm
It was established in 1993 in a lab in Egypt (one of the poorest countries to pursue research) that glyphosate causes cancer in vetro. The US acknowledged these findings (and other research) and they were removed from Entrez PubMed, the National Library of Medicine.
However, the issue truly is not merely cancer. Any scientist or physician who has no recognition of a microbiome, or recognition of antibiotics and antibiotic resistant organisms—please follow the link provided below. I am a layman, sick my adult life from exposure to glyphosate and 2,4-D I used on my lawn. Also involved in an accidental overspray, I have studied for thirty years and believe glyphosate poses a threat to life itself on earth. Since we hailed antibiotics, antibiotic resistance has been monitored. We have failed to clearly denote loudly and globally that glyphosate is patented by Monsanto as an antibiotic. With each exposure or consumption of glyphosate a kill effect occurs in the microbiome of humans, other animals, fish as well as plants. To simplify, the human animal cannot withstand a constant assault now found in the very rain. I became a participant to explore and locate one single place in the US where Roundup is not used. Such a location does not exist.
Humans must maintain a protective gut flora. The unfortunate truth is that the linings of human organs are very thin as in the prostate as an example (thinner than paper). “Leaky gut” is highly recognized in our society. Metastatic cancer is recognized in a similar way.
The rise in autism spectrum disorder alone is proof enough that the gut-brain axis can be adversely and irrevocably affected by leaky gut syndrome, and the leakage is not confined to the gut alone. Scientific findings show a similar behavior in the brain.
Statistically, living near golf courses carries an increase in Parkinson’s disease of 20%. We have been aware of these statistics for decades.
ALL “cides” kill living prebiotic, probiotic and postbiotic material throughout humans, animals and soils. Plants and humans indirectly share the shikamate pathway. Dow was able to market Roundup by thinly veiled assertions that the shikamate system does NOT occur in humans. Whether it is acknowledged or not, this simple finding supports that foods treated with glyphosate deplete manganese and other minerals crucial to human and soil survival. The numbers of increase in cancer, neurodegerative disease, chronic sinusitis, low immune function, chronic fatiguing diseases attest to the greed-borne unscientific attempt to profit from toxins such as glyphosate going against profitable and sustainable organic farming practices proven through years.
Ownership of seed, destruction of soils, dismantling of societal relationships is the outcome of irreverent farming practices. Despite scientific research, the use of glyphosate on lawns is dangerous and dispicable given the research that proves a close link to the gut and brain. To the point cited above that animals are despicably used to conduct the study of Roundup, millions of dogs and cats are exposed to glyphosate on lawns each day across the US—one of a few nations that has NOT BANNED GLYPHOSATE FROM THEIR BORDERS!
Because it destroys the gut flora (because it is an antibiotic) any veterinarian who has not seen a cat drooling and dying (diagnosed with autoimmune disease that cleared when the cat was relocated) after being sprayed with glyphosate has a very shallow knowledge base of the damage glyphosate can bring to all living organisms.
I find the responses in these replies devoid of respect for all things living on earth and the earth itself. Please join the movement by major corporations in America to stop the blight caused by Monsanto and Dow.
Go to https://m.youtube.com/watch?v=4tBTv0I5-qk Dr. Zach Bush is an expert on the damage done to individuals in our society. If glyphosate has such undeniable safety claims why do we appoint the head of the very industries to head the EPA? And watching this (one of several YouTube discussions) reveals the very name being changed to divert attention from “Roundup Ready” so as to remind me of a criminal attempting to change his appearance after a crime in order to avoid recognition!
We need to wake up and realize that when scientists who have realized their chemotherapeutic agents resemble the cause; a majority of Americans are diabetic such that we have a National Emergency in our military, disabled children, couples who cannot conceive, and explore the reason behind these and other health events, it is not time to throw mud. It is time to act. Our very existence is at stake.
Glyphosate is now found in rainwater. It is found in a high percentage of drinking water.
Please look into Dr. Zach Bush and see the fantastic progress he and others have made. Thank you.
August 27, 2022 @ 3:24 pm
Please continue your research. You are on the right track. Glyphosate is toxic to all life on the planet. Monsanto/Bayer must be held accountable for all the lives they have destroyed.
August 22, 2022 @ 11:30 pm
The original journal article and author of this article both state that the dosages are not human specific, but are based on other reports and are still well under the NOAEL (no observable adverse effect level). Another note, mice metabolize substances faster than humans: they have faster metabolisms, and studies increase the dosages of agents tested agents in mice, its a known fact in the pharmacology world (see https://www.novoprolabs.com/support/articles/how-to-convert-human-dose-between-animal-dose-201905311569.html).
They state that followup work will look at human relevant dosages, and some have actually published the negative effects of much lower dosages (see https://www.mdpi.com/1422-0067/23/9/4605/htm). Glyphosate usage has gone up substantially over the last couple of decades and to simply say we should stop investigating it because of the dosages used for this first proof of concept (i.e., crossing the blood brain barrier) is wrong. I am curious to see what the authors publish moving forward, as this likely opened a whole new area of investigation.
August 22, 2022 @ 10:27 pm
How much did Bayer pay you for that nugget? How about considering exposure over many years and the residual impact, not to mention “pure glyphosate” doesn’t contain co-formulants which have been identified as potential carcinogens. Stick to farm animals deary.
August 19, 2022 @ 11:36 pm
glyphosate passes-thru the blood-brain barrier. our brain’s filter no less.
August 22, 2022 @ 6:59 am
I think the author is confused with doses.
In fact the acceptable daily intake (ADI) for consumers is set at 0.5mg/kg body weight per day (EU). and food monitoring shows people eat LESS THAN 1% or that i.e. 0.005mg/kg/day.
NO WHERE NEAR 500mg/kg/day!
That’s like eating a couple of table spoons or pure glyphosate! each day! (lots more if you are a bigger person than I am).
Speaking as a veterinarian, it sounds like this study just tried REALLY hard to poison rodents and I’m surprised these kinds of experiments get ethics approval. You could poison animals force fed coffee, chocolate, hand soap, toothpaste… etc with similarly ridiculous doses. It proves a lack of inspiration for worthy reseach topics and your authors trying to mislead peopke – but not a worry about well monitored herbicides.
stop trying to scare people, stop crappy animal testing.
August 27, 2022 @ 4:26 pm
Why is ANY dose level of glyphosate acceptable? Why can’t we all agree it’s time to explore natural ways to farm that don’t rely so much on the mighty dollar, and expose us to any potential toxicity? Humans are advancing in so many areas, why would we settle for this?
August 27, 2022 @ 6:41 pm
Jennifer, I’m Susan Jannarone. A doctor who previously developed chemotherapy agents believes you are correct. Please scroll up to find my posts if I’m not able to provide the links here. I haven’t tried doing that. I have two long posts above.
https://m.youtube.com/watch?v=JszHrMZ7dx4 Monsanto deception
I’m going to order the supplements that decrease glyphosate. There are others selling the same sort of thing. After my pesticide overspray I cannot be in the US due to my exquisite sensitivity but S. Africa where my family lives doesn’t use pesticides such as Roundup. There I can breathe, eat, sleep, and don’t get tired.