toxic exposures Archives

January 10, 2024

Doctors raise alarm on dropping global fertility rate, environmental pollutants cited

By Shannon Kelleher

Health researchers from around the world are sounding an alarm on a persistent drop in fertility rates, pointing to environmental pollutants among a wide range of factors that they argue need to be urgently addressed in a paper published Wednesday.

Both male and female reproductive health is deteriorating, especially in industrialized regions, suggesting important roles of environmental factors, such as endocrine-disrupting chemicals and pesticides, the authors of the paper state. Studies indicate that the global fertility rate is dropping, with 93% of all countries worldwide expected to dip below levels necessary to keep populations from shrinking by 2100.

The trend is driven, in part, by the impacts of exposure to toxic chemicals, as well as lifestyle factors such as smoking and obesity, according to the 11 researchers authoring the paper, which was published Wednesday in the journal Human Reproduction Update. The researchers – who come from multiple countries, including the United States, Australia, South Africa, Greece, and Denmark – reviewed dozens of studies in coming to their central conclusion that public policy, research and medical access must be stronger on the topic of fertility.

In conjunction with the publication of the paper, the International Federation of Fertility Societies (IFFS), which represents fertility societies in 65 countries, is launching a global campaign Wednesday seeking to push policymakers to make fertility care more affordable, accessible, and equitable, and to adopt policies that aid fertility, including reducing exposures to air pollution and other harmful chemicals linked to reproductive harm.

The paper says that “due to multiple societal and environmental changes, it is important to emphasize that globally between 48 million couples and 186 million individuals of reproductive age live with infertility.” They call infertility “a common chronic disease affecting many reproductive-age women and men.”

Data on the decline in total fertility rate around the world – the number of children each woman gives birth to, a critical factor in population growth – is “pretty remarkable,” said Tracey Woodruff, a professor at the University of California, San Francisco School of Medicine who was not involved in the paper.

“This is really an important issue because it impinges on people’s ability to choose pregnancy should they want to choose pregnancy,” said Woodruff

Among environmental pollutants, endocrine-disrupting chemicals, in particular, are a fertility concern, she said. “We know that the number and amount of them are increasing and we know that some of them can directly impact male and female reproductive health.”

It is difficult to fully calculate the role of environmental pollutants in infertility since “we only have data on a very small proportion of endocrine-disrupting chemicals to which we’re exposed,” she added.

About one in six people struggle with infertility, according to the World Health Organization. Research suggests sperm count in men has declined by 1.6% per year since 1973, although the impact on global fertility is unknown, the paper states.

April 7, 2023

New book details behind-the-scenes drama of Roundup trials

It’s been nearly eight years since the filing of the first US lawsuit alleging that Roundup weed killer and other herbicides made by Monsanto with a chemical called glyphosate can cause non-Hodgkin lymphoma (NHL). Fueled by findings from international cancer scientists, the allegations sprawled into nationwide litigation that ultimately included more than 100,000 plaintiffs, and unveiled long-hidden corporate secrets.

After plaintiffs won the first three trials, Bayer AG, which bought Monsanto in 2018 as the first Roundup trial was getting underway, agreed to pay more than $11 billion to try to settle the litigation, and pledged to withdraw Roundup and other glyphosate-based products from the US consumer market. Though most plaintiffs have now settled, many opted out of the settlement, and trials around the US are continuing.

Chadi Nabhan, MD, MBA, a lymphoma specialist formerly with the University of Chicago, has been a key expert witness in many of the plaintiffs’ cases, including those who won the first three trials.

In his new book, Toxic Exposure: The True Story behind the Monsanto Trials and the Search for Justice, Nabhan gives readers a behind-the-scenes look into how he and other experts working for the plaintiffs’ lawyers pieced together a complicated scientific puzzle that convinced jurors of the company’s liability and the link between Roundup and NHL.

The book details what it was like for Nabhan to join the fight against Monsanto, explains how the trials affected his life’s trajectory, and highlights the struggles faced by plaintiffs suffering from cancer. The New Lede sat down with Nabhan to discuss the link between Roundup and NHL, his experiences at the trials, and what he thinks the public should know.