herbicide

April 1, 2024

Concerned about developing babies, EPA warns about danger of weed killer used on farms, golf courses

By Jonathan Hettinger

The US Environmental Protection Agency (EPA) on Monday took the rare step of issuing a warning about “serious, permanent, and irreversible health risks” associated with a chemical used to kill weeds on farms and golf courses and athletic fields.

Citing “significant health risks to pregnant individuals and their developing babies,” the agency said farmworkers and others handling dimethyl tetrachloroterephthalate, more commonly known as DCPA, were at risk, as are people who might play on courses or fields recently sprayed with the pesticide.

The most serious risks extend to the developing babies of pregnant women, especially those handling DCPA products. The agency said pregnant women exposed to DCPA could experience changes to fetal thyroid hormone levels, which are linked to low birth weight, impaired brain development, decreased IQ, and impaired motor skills later in life. Though product labels say people should stay out of fields for 12 hours after they are sprayed with DCPA, the EPA said evidence indicates that in many cases, sprayed fields would be unsafe for 25 days or more. The agency additionally said that mothers and their developing babies could be at risk if they live near areas where DCPA is used because the pesticide can drift.

“EPA has determined that currently registered products containing the herbicide DCPA likely cannot be used under current label directions without posing serious risks of concern in humans,” Ed Messina, director of the Office of Pesticide Programs, stated in a letter to AMVAC, a California-based company that is the sole manufacturer of the pesticide.

The product is primarily used to control weeds on crops such as broccoli, Brussels sprouts, cabbage and onions, though it is also used in some non-agricultural settings. Last year, AMVAC agreed to end its use on turf, citing health concerns.

The EPA is currently reviewing whether to reapprove DCPA. Though the agency rarely takes the step of canceling a pesticide, it is considering that route, including suspending DCPA during review process, the agency said.

“Due to the serious potential risks posed by DCPA use, EPA will be pursuing these regulatory options as soon as practicable,” Messina wrote in the communication to AMVAC.

September 5, 2023

Letter from the editor: The saga of Syngenta, a scientist, and a subpoena

By Carey Gillam

Six months ago neurologist Dr. E. Ray Dorsey and a colleague authored an article titled “Paraquat, Parkinson’s Disease and Agnotology,” which spotlighted secrets unearthed from within the corporate files of paraquat maker Syngenta AG. The article was published March 6, 2023, in Movement Disorders, the official journal of the International Parkinson and Movement Disorder Society.

In the article, Dorsey and co-author neurologist Dr. Amit Ray pointed to stories I wrote for The New Lede and The Guardian that were based upon thousands of pages of the company’s internal documents dating back to the 1950s. Those files revealed many corporate secrets related to paraquat safety and the weed killer’s potential connection to the dreaded, incurable brain disease known as Parkinson’s.

“Knowledge of the toxic effects of paraquat is alleged to have been hidden for decades,” Dorsey’s article stated. “All the while, the manufacturer continues to maintain that paraquat does not cause Parkinson’s disease. Actions like these should be recognized for what they are: attacks on science, attacks on scientists, and attacks on the health of the public.”

“This report and the company’s own findings now indicate that we know what one cause of Parkinson’s disease is—paraquat,” the article stated. “With this conclusion, paraquat should be banned, and the search for other causative factors in the environment should accelerate.”

(Dr. E. Ray Dorsey)
The statements published in the article did not sit well with Syngenta, to put it mildly.

Syngenta has spent the last few months engaging in what Dorsey’s defenders say is the latest effort in a history of chemical industry actions to harass, or otherwise smear, scientists whose work threatens corporate interests.

Since the article’s publication, Syngenta has been demanding that Dorsey turn over his private files – emails, notes, article drafts, and other records. The company is publicly accusing Dorsey of publishing his article not as a sincere scientific commentary, but as part of a conspiracy to engineer evidence that could be used by plaintiffs in sweeping, nationwide litigation brought by people alleging they developed Parkinson’s because of exposure to Syngenta’s paraquat herbicide.

After Dorsey balked at Syngenta’s demands, citing the fact that he has no connection to the litigation, the company last month asked a federal judge to force Dorsey to turn over his files.

August 22, 2023

Science takes center stage in court hearing over paraquat and Parkinson’s disease

By Carey Gillam

Testimony is underway this week in a key federal court hearing aimed at examining scientific evidence about allegations that a widely used weedkiller called paraquat causes Parkinson’s disease.

The outcome of the hearing, which began Monday and runs through Thursday in East St. Louis, Illinois, is critical for thousands of people with Parkinson’s who are suing paraquat maker Syngenta AG and former paraquat distributor Chevron.

The plaintiffs claim scientific research shows that exposure to paraquat significantly increases the risk of Parkinson’s disease, but instead of warning users the companies prioritized paraquat sales over human health. The first trial is scheduled to start in October.

When this week’s hearing concludes, US District Court Chief Judge Nancy Rosenstengel will determine whether or not the plaintiffs’ experts and their scientific analyses will be allowed as evidence in the upcoming trials. Syngenta and Chevron are asking the judge to bar each of the plaintiffs’ scientific experts from testifying, saying their experience is lacking and their analyses are deeply flawed. If the judge agrees, the plaintiffs’ cases could be virtually unwinnable.

More than 4,600 plaintiffs are part of the multidistrict litigation (MDL) being overseen by Rosenstengel. More cases are pending in different jurisdictions around the US.

Syngenta and Chevron deny paraquat causes Parkinson’s and are fighting the lawsuits. The companies say the weight of scientific evidence demonstrates no causal link between the chemical and the disease.

Plaintiff’s lawyers told the judge their case will rely in part on years of animal studies showing that paraquat interacts in the brain to kill specific cells in a manner that is a hallmark of Parkinson’s disease. Human studies also support their case, the lawyers said. When the cases go to trial, they plan to present testimony from several expert witnesses supporting their allegations.

On Tuesday, the hearing turned to testimony by one of those expert witnesses – Cornell professor of epidemiology Martin Wells. Under oath, Wells told the judge that his analysis of years of published research led him to conclude that people exposed to paraquat have a risk of developing Parkinson’s disease that is substantially higher than for people not exposed to the weed killer.

Wells calculated an odds ratio of 2.8 with respect to paraquat’s causal relationship to Parkinson’s disease, meaning the risk of disease resulting from paraquat exposure was 180 times higher than the odds absent that exposure.

August 20, 2023

Conflict of interest alleged in Roundup case in Monsanto’s home town

By Carey Gillam

Lawyers representing a man who blames his cancer on exposure to Monsanto’s Roundup weed killer are crying foul over what they say are close personal ties between a lead Monsanto lawyer and a special magistrate helping oversee the Roundup litigation.

In an Aug. 17 court filing, the plaintiffs’ attorneys asked for St. Louis County special master Robert Blitz to be disqualified from his role in the litigation because of an “appearance of impropriety” and questions about his impartiality.

A hearing on the matter is set for Tuesday.

There are dozens of plaintiffs named in the case, and all allege that exposure to Monsanto’s glyphosate-based Roundup herbicide caused them to develop non-Hodgkin lymphoma (NHL).

One of the plaintiffs, Mark McCostlin, of Lenexa, Kansas, is set to go to trial against Monsanto in St. Louis County Circuit Court in early September.

The motion alleges that Monsanto lead attorney James Bennett “has a close relationship” with special master Blitz. The two men worked together as co-counsel in a separate case, and Bennett also has personally acted as legal counsel for Blitz and for his law firm, according to the motion.

Additionally, the two men are “effectively economic partners” in a contingency fee case that brought their two law firms $276.5 million in fees, which they split, according to the motion.

“Their relationship creates a conflict of interest such that Blitz is not qualified to serve as special master in any case in which Bennett is trial counsel,” the motion states.

May 25, 2023

Bayer investors granted class-action status in lawsuit over Monsanto deal

A federal judge has given the green light for a class-action lawsuit to proceed against Bayer AG brought by investors unhappy with the company’s $63 billion purchase of Monsanto Co. in 2018.

The suit, brought by three pension funds, alleges that Bayer AG misled investors over the risks of the acquisition and failed to properly perform due diligence before buying Monsanto, which at that time was the world’s largest seed company and the maker of the popular, but controversial, Roundup weedkiller.

Just weeks after closing the deal, Bayer shares plunged when Monsanto lost a bellwether trial brought by a California groundskeeper who alleged he developed non-Hodgkin lymphoma due to his exposure to Monsanto’s weed killer. The loss triggered a flood of additional litigation and ultimately led Bayer to agree in 2020 to pay roughly $11 billion to try to settle similar claims brought by more than 100,000 plaintiffs.

Bayer’s purchase of Monsanto was dubbed one of the “worst corporate deals” in recent history by the Wall Street Journal.

“These declines in the value of Bayer … caused Lead Plaintiffs and other Class members to suffer significant loss and damages,” wrote the plaintiffs’ law firm, Cohen Milstein, in a statement. ”

The lead plaintiffs in the action are the Sheet Metal Workers’ National Pension Fund and the International Brotherhood of Teamsters Local No. 710 Pension Fund, along with an additional plaintiff – the International Union of Operating Engineers Pension Fund of Eastern Pennsylvania and Delaware.

March 16, 2023

Monsanto accused of wrongly excluding non-US citizen from Roundup settlement

By Huanjia Zhang

(This story was originally published in Environmental Health News and is republished here with permission.)

Monsanto Co. and its corporate parent Bayer are facing a federal lawsuit for civil rights violations after they allegedly excluded a farmworker from a Roundup cancer settlement because of her immigration status.

According to the lawsuit, which was filed in the US District Court for the Western District of Virginia, plaintiff Elvira Reyes-Hernandez is a migrant farmworker who worked on Virginia tree farms between 2015 and 2018, during which she sprayed the herbicide Roundup regularly.

In 2015, the World Health Organization’s International Agency for Research on Cancer (IARC) listed glyphosate, the active ingredient in Roundup, as “probably carcinogenic to humans.” Over the years, a wide body of scientific evidence has also pointed to glyphosate exposure as causing an increased risk of non-Hodgkin lymphoma.

Reyes-Hernandez was diagnosed with non-Hodgkin lymphoma in 2019 and subsequently sued Monsanto, claiming that Roundup exposure had a role in causing her cancer.

“Monsanto is very likely making calculated risks based on the characteristics of the people who are using their products,” said Katy Youker, an attorney for Lawyers’ Committee for Civil Rights Under Law and a co-counsel for the case.

By excluding non-US citizens from the settlement program, she said, Monsanto is effectively putting up a huge barrier for migrant farmworkers — most of whom do not have citizenship but are at the forefront of Roundup exposure — from seeking restitution.

This case could send an encouraging message to migrant and undocumented farmworkers who wish to bring legal action against the company. However, legal experts and farmworker advocates are still pessimistic about the prospect of them coming forward, especially when facing a myriad of hurdles and obstacles.

March 1, 2023

California researchers link popular weedkiller to health problems in young adults

By Carey Gillam

Children exposed to a weedkiller commonly used in farming, as well as on residential yards and school playgrounds, appear to be at increased risk for liver inflammation and metabolic disorders in young adulthood and more serious diseases later in life, according to a study published Wednesday in the journal Environmental Health Perspectives.

The research, which was conducted by several California scientists and health researchers, including from the University of California, Berkeley School of Public Health, is the latest of many studies linking glyphosate herbicide to human health problems.

Glyphosate is better known as the active ingredient in Monsanto’s Roundup products as well as scores of other weedkilling brands sold around the world. The chemical is considered the most widely used herbicide in history, and residues are commonly present in food and water, as well as in human urine.

Monsanto and Bayer AG, which bought Monsanto in 2018, maintain that Roundup and other glyphosate-based herbicides are safe when used as directed, and say the weight of scientific evidence demonstrates that safety. But more than 100,000 people in the US have alleged exposure to the weedkiller caused them to develop non-Hodgkin lymphoma. Many independent scientific studies have linked glyphosate to cancers as well as liver disease, endocrine disruption and other health problems.

In the new study, researchers tracked 480 “mother-and-child duos” who live in the Salinas Valley of California, a key agricultural area, analyzing levels of glyphosate weed killer used in the area and levels of the weedkiller present in the urine of the mothers while they were pregnant and in the children as they grew. They also took into account levels of a degradation product of glyphosate known as AMPA in the urine of the study subjects. The researchers then assessed the liver and metabolic health of the children at the age of 18.

They concluded that higher levels of glyphosate residue and AMPA in urine in childhood and adolescence were associated with higher risk of liver inflammation and metabolic disorders in young adulthood. In addition, they found that agricultural use of glyphosate near participants’ homes from birth and up through age five was associated with metabolic disorders at age 18. Metabolic disorders in youth can lead to heart disease, stroke, type 2 diabetes, and liver disease later in life.

Both metabolic problems and liver disorders are increasing among children and young adults, according to the study.

January 19, 2023

New US research finds “worrying” evidence linking Monsanto weedkiller to cancer

By Carey Gillam

New research by top US government scientists has found that people exposed to the widely used weed killing chemical glyphosate have biomarkers in their urine linked to the development of cancer and other diseases.

The study, published last week in the Journal of the National Cancer Institute, measured glyphosate levels in the urine of farmers and other study participants and determined that the presence of the pesticide was associated with signs of a reaction in the body called oxidative stress, a condition that causes damage to DNA. Oxidative stress is considered by health experts as a key characteristic of carcinogens.

The authors of the paper – 10 scientists with the National Institutes of Health and two from the Centers for Disease Control and Prevention (CDC) – concluded that their study “contributes to the weight of evidence supporting an association between glyphosate exposure and oxidative stress in humans.” They also noted that “accumulating evidence supports the role of oxidative stress in the pathogenesis of hematologic cancers,” such as lymphoma, myeloma and leukemia.

“Oxidative stress is not something you want to have,” said Linda Birnbaum, a toxicologist and former director of the National Institute for Environmental Health Sciences. “This study increases our understanding that glyphosate has the potential to cause cancer.”

The study findings come after the CDC reported last year that more than 80% of urine samples drawn from children and adults contained glyphosate. The CDC reported that out of 2,310 urine samples taken from a group of Americans intended to be representative of the US population, 1,885 were laced with detectable traces of glyphosate.

Glyphosate is the most heavily applied herbicide in history, both in the US and globally. One of the best-known glyphosate-based products is Monsanto’s Roundup weedkiller. Roundup has been used by farmers as well as consumers for more than 40 years. Monsanto has always assured the public and regulators that exposure to the weed killer does not pose a threat to human health, but many independent scientists say there is a wealth of evidence to contradict those assurances.

People are exposed to glyphosate by using products made with the chemical and also by eating food and drinking water contaminated with the pesticide. Scientists have found glyphosate residues in an array of popular foods and in waterways across the US.

Notably, in the new paper, the NIH and CDC scientists said that while their study focused on farmers who were exposed to glyphosate when they sprayed it on fields, they saw similar results in “non-farmers.”

The findings suggest “these effects may apply more broadly to the general population who are primarily exposed through ingestion of contaminated food and water or residential applications,” the study authors wrote.

The study is so significant that it warrants regulatory attention, said some independent scientists.

“This is a top level team of investigators and a highly credible study to which regulators need to pay attention,” said Phil Landrigan, a pediatrician and epidemiologist who worked for years at the CDC and the Environmental Protection Agency (EPA) and now directs the Program for Global Public Health and the Common Good at Boston College.

Michael Antoniou, a scientist with the department of medical and molecular genetics at King’s College in London who has been researching glyphosate for years, said the results were “worrying,” with “major health implications.”

October 27, 2022

Amid calls for ban on weed killer linked to Parkinson’s, a battle over science

By Carey Gillam

When US regulators issued a 2019 assessment of the widely used farm chemical paraquat, they determined that even though multiple scientific studies linked the chemical to Parkinson’s disease, that work was outweighed by other studies that did not find such links. Overall, the weight of scientific evidence was “insufficient” to prove paraquat causes the brain disease, officials with the US Environmental Protection Agency (EPA) declared.

The EPA reiterated its assessment in a 2021 report. The agency said after extensive analysis of numerous factors, including concerns about Parkinson’s risk, it determined farmers could safely continue to apply the weed killer across millions of US acres to help in the production of soybeans, corn, cotton and an array of other crops.

The determination has been significant for Syngenta, the longtime maker of paraquat weed killers. The company is facing calls in the US for a paraquat ban, as well as more than 2,000 legal claims brought by farmers and others alleging they developed Parkinson’s disease because of their exposure to paraquat.

Syngenta cites the EPA assessment of the science on paraquat in defense of the pesticide, and says scientific research “does not support” a causal relationship between the chemical and the disease. On a Syngenta-run paraquat information website, the company highlights several studies it says also backs that position, including many conducted by company scientists or by outside scientists who received company funding for their work.

Last week the Guardian and The New Lede reported that internal corporate records show Syngenta had knowledge of science linking paraquat to Parkinson’s decades ago but sought both to refute the evidence with various secret tactics. The documents are available at the Paraquat Papers Media Library.

US farmworker, health and environmental advocacy groups say in contrast to the corporate science, research conducted by independent scientists provides abundant evidence of paraquat’s ability to cause Parkinson’s and other health dangers, and the EPA is improperly discounting that body of research.

More than 50 groups have called for the US to follow the lead of dozens of other countries in banning paraquat. The Michael J. Fox Foundation for Parkinson’s Research submitted a petition to the EPA with 107,000 signatories calling for a ban. The foundation cited a study that found people exposed to paraquat in their teens or as young adults had an increased Parkinson’s risk of 200 to 600 percent, depending on the overall exposure.

August 26, 2022

For first time, Bayer CEO targeted to give testimony in Roundup litigation

By Carey Gillam

Bayer AG CEO Werner Baumann can be required to provide testimony in ongoing Roundup litigation despite efforts by Bayer to block such action, according to a recent court order.

A judge in Arkansas ruled that lawyers for plaintiffs in the litigation may travel to Germany, where Bayer is based, and take deposition testimony from the executive to be used as evidence. The judge directed Baumann to sit for the questioning within 90 days. The order is a first in the sweeping Roundup litigation, which began in 2015.

Baumann was instrumental in driving Bayer to buy Monsanto in 2018 for $63 billion, and he has been the public face for the company’s continued insistence that Monsanto’s Roundup, and other glyphosate-based herbicides, are not carcinogenic.

The plaintiffs lawyers say it is these representations by Baumann and others that open up Bayer to allegations of “fraudulent concealment,” and is part of the reason they want to depose him. The evidence and trials held to date have focused on scientific studies that mostly predate the acquisition, as well as internal Monsanto documents and other records, but have not explored corporate actions by Bayer.

Lawyers for Bayer sought a protective order preventing a deposition of Baumann, and on Thursday asked the judge to reconsider his ruling, saying reconsideration is needed to prevent a “miscarriage of justice.” The company said additionally that if the court will not reconsider, it wants the deposition conducted “in accordance with the Hague Convention.”